B.Selected peer-reviewed publications (in chronological order): (Selected papers out of 290)

Chang, Y. F., R. Young., D. Post, and D. K. Struck. 1987. Identification and characterization of the Pasteurella haemolytica leukotoxin. Infect. Immun. 55: 2348-2354.
Chang, Y. F., R. Young, and  D. K. Struck. 1989. Cloning and characterization of a  hemolysin gene from Actinobacillus (Haemophilus) pleuropneumoniae DNA &Cell biology: 8: 635-647.
Cruz, W.T., R. Young, Y. F. Chang, and D.K. Struck. 1990. Deletion analysis resolves cell-binding and lytic domains of the Pasteurella leukotoxin. Mol. Microbiol. 4: 1933-1939.
Chang, Y. F., R. Young, and D.K. Struck. 1991. The Actinobacillus pleuropneumoniae determinant:  unlinked appCA and appBD loci flanked by pseudogenes. J. Bacteriol. 173: 5151-5158.
McWhinney, D.R., Y. F. Chang, R.Young, and D. K.Struck. 1992  Separable domains define target cell specificities of the RTX hemolysin from Actinobacillus pleuropneumoniae. J. Bacteriol. 174: 291-297.
Appel, M. J.G., S. Allan, R. H. Jacobson, T.L. Lauderdale, Y. F. Chang, S. J. Shin, J. Thomford, R. Todhunter, and B. A. Summers. 1993. Experimental Lyme disease in dogs produced arthritis and persistent infection. J. Infect. Dis. 167: 651-664.
Chang, Y. F., D. P. Ma, J. Shi, and M. M. Chengappa. 1993. Molecular characterization of a leukotoxin gene from a Pasteurella haemolytica-like organism, encoding a new member of RTX family. Infect. Immun. 61: 2089-2095.
Chang, Y. F., J. Shi, D. P. Ma, S. J. Shin, and D. H. Lein. 1993. Molecular analysis of the Actinobacillus pleuropneumoniae RTX toxin-III gene cluster. DNA. Cell Biol. 12: 351-362.
Chang, Y. F., M. J. Appel, R. H. Jacobson, S. J. Shin, P. Harpending,  R. Straubinger, L. A. Patrican, H. Mohammed, and B. A. Summers. 1995. Recombinant OspA protects dogs against infection and disease caused by Borrelia burgdorferi. Infect. Immun. 63: 3543-3549.
Chang, Y. F., R. Straubinger, R. H. Jacobson, J. B. Kim, T. J. Kim, D. Kim, S. J. Shin, and M. J. G. Appel. 1996. Dissemination of Borrelia burdorferi after experimental infection in dogs. J. Spiro. Tick-Borne Dis. 3: 80-86.
Straubinger, R. K., A. F. Straubinger, L. Harter, R. H. Jacobson, Y. F. Chang, B. A. Summers, H. N. Erb, and M. J. G. Appel. 1997.  Borrelia burgdorferi migration and proliferation causes up-regulation of interleukin-8 in synovial membranes of experimentally infected dogs. Infect. Immun. 65: 1273-1285.
Straubinger, R. K., B. A. Summers, Y. F. Chang, and M. J. G. Appel. 1997. Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment. J. Clin. Microbiol. 35: 111-116.
Straubinger, R. K., A. F. Straubinger, R. H. Jacobson, Y. F. Chang, B. A. Summers, H. N. Erb, and M. J. G. Appel. 1997.  Two lessons from the canine model of Lyme disease: migration of Borrelia burgdorferi in tissue and persistence after antibiotic treatment. J. Spiro.Tick-Borne Dis. 3: 24-31.
McDonough P. L., R.  H.  Jacobson, J. F. Timoney, A. Mutalib, D. C. Kradel, Y. F. Chang, S. J. Shin, D. H. Lein, S. Trock, and K. Wheeler. 1998. Interpretations of antibody responses to Salmonella enterica serotype Enteritidis gm flagellin in poultry flocks are enhanced by a Kinetics-based enzyme-linked immunosorbent assay. Clin. Diagn. Lab. Immunol. 5: 550-555.
Chang, Y. F., V. Novosel, S. P. McDonough, R. H. Jacobson, C. F. Chang, T. Divers, F. W. Quimby, S. Shin, and D. H. Lein. 1999. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer surface protein A (OspA) in horses. Vaccine 18: 540-548.
Chang, Y. F., S. P. McDonough, K.S. Shin, C. F. Chang, and T. Divers. 2000. Human granulocytic ehrlichiosis agent (HGE) infection in a pony vaccinated with recombinant OspA vaccine and challenged by exposure to naturally infected ticks. Clin. Diag. Lab. Immunol. 7: 68-71.
Simpson, K.W., D. Strauss-Ayali, E. Scanziani, R. K. Straubinger, P. L. McDonough, A.F. Straubinger, Y. F. Chang, C. Domeneghini, N. Arebi, and J. Calm. 2000. Helicobacter felis infection is associated with lymphpoid follicular hyperplasia and mild gastritis but normal gastric secretory function in cats. Infect. Immun. 68: 779-790.
Simpson, K.W., D. Strauss-Ayali, E. Scanziani, R. K. Straubinger, P. L. McDonough, A. F. Straubinger, Y. F. Chang, M. Esteves, J. G. Fox, C. Domeneghini, N. Arebi, and J. Calam. 2001. Gastric secretory function in cats with Helicobacter pylori infection. Helicobacter 6: 1-14.
Raghavan, P. U. M., Y. F. Chang,  S. S. D. Jusuf, S. Artiushin, J. F. Timoney, S. P. McDonough, S. C. Barr, T. J. Divers, P. McDonough, K. W. Simpson, and H. Mohammed. 2002. Cloning and molecular characterization of an immunogenic LigA of Leptospira interrogans. Infect. Immun. 70:5924-5930.
Teng, C.H., R. U.M. Palaniappan, and Y. F. Chang. 2003. Cloning and characterization of an Ehrlichia canis gene encoding a protein localized to the morula membrane. Infect. Immun. 71:2218-2225.
Palaniappan, R. U., Y. F. Chang, F. Hassan, S.P. McDonough, M.  Pough, S.C. Barr, K. W. Simpson, H. O. Mohammed, S. Shin, P. McDonough, R.  Zuerner, J. Qu,  & B. Roe. 2004. Expression of leptospiral immunoglobulin-like protein from Leptospiral interrogans and evaluation of its diagnostic potential in kinetic enzyme linked immunosorbent assay. J. Med. Microbiol. 53: 975-84.
Palaniappan, R. U., Y. F.  Chang, C. F. Chang, M. J. Pan, C. W. Yang, P. Harpending, S. P. McDonough, E. Dubovi, J. Qu, B. Roe and T. Divers^. 2005. Evaluation of lig-based conventional and real time PCR for the detection of pathogenic leptospires. Mol. Cell. Probes 19:111-117.
Shin, S.J., C.F. Chang, C. C. Chang, S. P. McDonough, B. Thompson, H.S. Yoo, and Y. F. Chang. 2005. In vitro cellular immune response to recombinant antigens of Mycobacterium avium subsp. paratuberculosis. Infect. Immun. 73:5074-5085.
Ku, Y.W., S. P. McDonough, R.U.M. Palaniappan, C. F. Chang, Y. F. Chang. 2005. Identification and characterization of in vivo attenuated mutants of Salmonella enterica serovar Choleraesuis using signature-tagged mutagenesis in a pig infection model. Infect. Immun. 73:8194-8203.
Raghavan, P. U. M.,  S. P. McDonough, T. J. Divers, C. S. Chen, M.J. Pan, M. Matsumoto and Y. F. Chang. 2006. Immunoprotection of recombinant leptospiral immunoglobulin like A protein (LigA) against Leptospira interrogans serovar Pomona infection. Infect. Immun. 74:1745-1750.
Palaniappan, R. U., Y. Zhang, D. Chiu, A. Torres, C. DebRoy, T. S. Whittam and Y. F. Chang. 2006. Differentiation of Escherichia coli pathotypes by oligonucleotide spotted array. J. Clin. Microbiol. 44:1495-1501.
Palaniappan, R. U., S. Ramanujam and Y. F. Chang. 2007. Leptospirosis: Pathogenesis, Immunity, and Diagnosis. Current Opinion Infect. Dis. 20:284-292.
Lin, Y.P. and Y. F. Chang. 2007. A domain of the Leptospira LigB contributes to high binding of fibronectin. Biochem. Biophy. Res. Comm. 362:443-448.
Chang, Y.F., C. S. Chen, R. U.M. Palaniappan, S. P. McDonough, W. Yang, M. J. Pan, and C. F. Chang. 2007. Immunogenicity and protection of the recombinant leptospiral immunogenic proteins as vaccine candidates. Vaccine 25: 8190-8197.
Faisal, S.M., W. Yan, C. S. Chen, R. U.M. Palaniappan, S. P. McDonough, and Y. F. Chang. 2008. Evaluation of protective immunity of Leptospira immunoglobulin like protein A (LigA) DNA vaccine against challenge in hamsters. Vaccine, 26:277-287.
Chen, L. H., K. Kathaperumal, C. J. Huang, S. P. McDonough, S. Stehman, B. Akey, J. Huntley, C.F. Chang and Y. F. Chang. 2008. Immune responses in mice to Mycobacterium avium subsp. paratuberculosis following vaccination with a novel 74F recombinant polyprotein. Vaccine 26:1253-1262.
Kathaperumal^, K., S. U. Park, S. P. McDonough, S. Stehman, B. Akey, J. Huntley, S. Wong, L. H. Chen, C.-F. Chang and Y. F. Chang. 2008. Vaccination with recombinant Mycobacterium avium subsp. paratuberculosis proteins induces differential immune responses and protects calves against infection by oral challenge. Vaccine, 26:1652-1663.
Scaria, S., P. U. M. Palaniappan, D. Chiu, J.A. Phan, L. Ponnala, P. McDonough, Y. T. Grohn, S. Porwollik, M. McClelland, C.S. Chiou, C. Chu and Y. F. Chang^. 2008. Microarray for molecular typing of Salmonella enterica serovars. Mol. Cell. Probes 22:238-243.
Park, S.U., K. Kathaperumal, S. McDonough, B. Akey, J. Huntley, J. P. Bannantine and Y.F. Chang. 2008. Immunization with a DNA vaccine cocktail induces a Th1 response and protects mice against Mycobacterium avium subsp. paratuberculosis. Vaccine 26:4329-4337.
Lin, Y.P. R. Raman, Y. Sharma, and Y. F. Chang. 2008. Calcium binds to Leptospiral immunoglobulin-like protein, LigB and modulates fibronectin-binding. J. Biol. Chem. 283:25140-25148. Scaria, J., A. Sreedharan, and Y. F. Chang. 2008. Microbial Diagnostic Array Workstation (MDAW): A web server for diagnostic array data storage, sharing and analysis. Source Code Biol. Med. 3:14-18. Kathaperumal, K,, V. Kumanan, S. McDonough, L. H. Chen, S. U. Park, M. A. Moreira, B. Akey, J. Huntley, C. F. Chang, and Y. F. Chang. 2009. Evaluation of immune responses and protective efficacy in a goat model following immunization with a coctail of recombinant antigens and a polyprotein of Mycobacterium avium subsp. paratuberculosis. Vaccine 27:123-135.
Faisal, S.M., W. Yan, S. P. McDonough, and Y. F. Chang. 2009. Leptospira immunoglobulin-like protein A variable region (LigAvar) incorporated in Liposomes and PLGA-Microspheres produces a robust immune response correlating to protective immunity. Vaccine 27:378-387.
Yan, W., S. M. Faisal, S. P. McDonough, T. J. Divers, S. C. Barr, M. J. Pan, C. F. Chang and Y.F. Chang. 2009. Recombinant Leptospira Immunoglobulin-Like Protein B (rLigB) protects hamsters against lethal Leptospira interrogans infection. Microbes Infect.11:230-237.
Janvilisri T., J. Scaria, A. Thompson, A. Nicholson, B. Limbargo, L. G. Arroyo, J. G. Songer, Y. T. Grohn, and Y. F. Chang. 2009. Microarray identification of Clostridium difficile core components and divergent regions associated with host origin. J. Bacteriol. 191:3881-3891.
Lin Y.P., D.W. Lee, S. P. McDonough, L. K. Nicholson, Y. Sharma, and Y. F. Chang.2009. Repeated domains of leptospira immunoglobulin-like proteins interact with elastin and tropoelastin. J. Biol. Chem. 284:19380-19391.
Lin Y.P., A. Greenwood, L. K. Nickolson, Y. Sharma, S. P.McDonough, and Y. F. Chang. 2009. Fibronectin binds to and induces conformational change in a disordered region of Leptospiral immunoglobulin-like protein B. J. Biol. Chem. 284:23547-23557.
Lin Y.P., A. Greenwood, L. W. Yan, K. Nickolson, Y. Sharma, S. P.McDonough, and Y. F. Chang. 2009. A novel fibronectin type III modules binding motif identified on C-terminus of Leptospiral Immunoglobulin-like protein, LigB. Biochem. Biophy. Res. Comm. 389:57-62.
Faisal, S.M., W. Yan, S. P. McDonough, and Y. F. Chang. 2009. Immune response and prophylactic efficacy of smegmosomes in a hamster model of leptospirosis. Vaccine, 27:6129-6136.
Faisal, S.M., W. Yan, S. P. McDonough, M. J. Pan, C. F. Chang and Y. F. Chang. 2009. Leptosome-associated antigens conferred significantly higher levels of protection against leptospirosis in hamsters compared to those associated with conventional liposomes. Vaccine, 27:6537-6545.
Chiou C.S., J. M. Lin, C. H. Chiu, C. H. Chu, S. W. Chen, Y. F. Chang, B. C. Weng, J. G. Tsay, C.L. Chen, C. H. Liu and C. Chu. 2009. Clonal dissemination of the multi-drug resistant Salmonella enterica serovar Braenderup, but not the serovar Bareilly, of prevalent serogroup C1 Salmonella from Taiwan. BMC Microbiol. 9:264.
Janvilisri T., J. Scaria, R. Gleed, S. Fubini, M. M. Bonkosky, Y. T. Grohn, and Y. F. Chang. 2010. Development of a microarray for identification of pathogenic Clostridium species. Diagn. Microbiol. Infect. Dis. 66:140-147.
Yan, W., S. M. Faisal, S. P. McDonough, C. F. Chang, M. J. Pan, and Y.F. Chang. 2010. Identification and characterization of OmpA-like proteins as novel vaccine candidates for Leptospirosis. Vaccine. 28:2277-2283.
Janvilisri T., J. Scaria, and Y. F. Chang. 2010. Transcriptional profiling of Clostridium difficile and Caco-2 cells during infection. J. Infect. Dis. 202:282-290.
Lin Y.P., S. P. McDonough, Y. Sharma and Y.F.  Chang. 2010. The terminal immunoglobulin-like repeats of LigA and LigB of Leptospira enhance their binding to gelatin binding domain of fibronectin and host cells. Plos one: 5:e11301.
Scaria, J., L.D Warnick, J. B. Kaneene, K. May, C. H. Teng and Y. F. Chang^. 2010. Comparison of phenotypic and genotypic antimicrobial profiles in Eschericia coli and Salmonella enterica from the same dairy cattle farms. Mole. Cell. Probes. 24:325-45.
Scaria, J., L. Ponnala, T. Janvilisri, W. Yan, L. A. Mueller and Y. F. Chang. 2010. Analysis of Ultra Low Genome Conservation in Clostridium difficile. PLoS One. 5: e15147.
Rama, R., V. Rajanikanth, R. U. M. Palaniappan, Y.P. Lin, H. He, S. P. McDonough, Y. Sharma and Y. F. Chang. 2010. Big Domains are Novel Ca²⁺-binding Modules: Evidences from Big Domains of Leptospira immunoglobulin-like (Lig) Proteins. PLoS One. e14377.
Lin, Y.P., C. J. Kuo, X. Koleci, S. P. McDonough, and Y. F. Chang. 2011. Manganese binds to Clostrdium difficile Fbp68 and is essential for fibronectin binding. J.  Biol. Chem. 286:3957-3969, 2011.
Lin, Y.P., S. P. McDonough, Y. Sharma, and Y. F. Chang. 2011. Leptospiral immunoglobulin-like protein (LigB) binds to the C-teminal fibrinogen αC domain inhibiting fibrin clot formation, platelet adhesion, and aggregation. Mol. Microbiol. 79:1063-1076.
Faisal S.M, J. W. Chen, S.P. McDonough, C.F. Chang, C.H. Teng, and Y.F. Chang. 2011. Immunostimulatory and antigen delivery properties of liposomes made up of total polar lipids from non-pathogenic bacteria leads to efficient induction of both innate and adaptive immune responses. Vaccine 29:2381-2391.
Scaria J., T. Janvilisri, S. Fubini, R. D. Gleed, S. P. McDonough, and Y.F. Chang. 2011. Clostridium difficile transcriptome analysis using pig ligated loop model reveals modulation of pathways not modulated in vitro. J. Infect. Dis. 203:1613-1620.
Cao Y, S.M. Faisal,W. Yan, Y.C. Chang,S. P. McDonough,N. Zhang, B. L.Akey, and Y. F. Chang. 2011. Evaluation of novel fusion proteins derived from extracellular matrix binding domains of LigB as vaccine candidates against leptospirosis in a hamster model. Vaccine. 29:7379-86
Liu B, Mehmood K, Nabi F, Chang YF, Tang Z, Li Y, Zhang H. 2021. Mosquito-Borne Infectious Diseases in China, 2019. Travel Med Infect Dis. 2021 Apr 1:102050.
Chen J.W, S. M.Faisal, S. Chandra, S. P. McDonough, M. A. Moreira, J. Scaria, C. F. Chang, J. P. Bannantine, B. Akey B, and Y. F. Chang. 2012 Immunogenicity and protective efficacy of the Mycobacterium avium subsp. paratuberculosis attenuated mutants against challenge in a mouse model. Vaccine. 30:3015-3025.
Kuo C.J, H. Bell, C. L. Hsieh, C. P. Ptak, and Y. F. Chang. 2012. The novel Mycobacteria antigen 85 complex binding motif on Fibronectin. J Biol Chem. 287:1892-1902.
Mao BH, Chang YF, Scaria J, Chang CC, Chou LW, Tien N, Wu JJ, Tseng CC, Wang MC, Chang CC, Hsu YM, Teng CH. 2012. Identification of Escherichia coli genes associated with urinary tract infections. J. Clin. Microbiol. 50:449-456.
Chen, J.W., J. Scaria and Y. F. Chang. 2012. Phenotypic and transcriptomic response of auxotrophic Mycobacterium avium subsp. paratuberculosis  leuD mutant under environmental stress. PLoS one. 7:e37884.
Janvilisri, T., J. Scaria, C. H. Teng,  S. P. McDonough, R. D. Gleed, S. L Fubini, S. Zhang, B. L. Akey, Y.F. Chang. 2012. Temporal differential proteomes of Clostridium difficile in the pig ileal-ligated loop model. PLoS one. 7: e45608.
Chandra S., S. M. Faisal, J. W. Chen, T.T. Chen, S. P. McDonough, S. Liu,  M. A. P. Moreira, B. L. Akey, C. F. Chang, and Y.F. Chang. 2012. Immune response and protective efficacy of live attenuated Salmonella vaccine expressing antigens of Mycobacterium avium subsp. paratuberculosis against challenge in mice. Vaccine, 31:242-251
Stabel, J.R., A, Barnhill, J. P. Bannantine, Y. F. Chang, and M. A. Osman. 2012. Evaluation of protection in a mouse model after vaccination with Mycobacterium avium subsp. paratuberculois protein cocktails. Vaccine, 31(1):127-34.
Faisal S.M., S. P. McDonough, and Y.F. Chang. 2012. Chapter 8. Leptospira: Strategies for evasion of host immunity and persistence. In the Pathogenic Spirochetes: strategies for evasion of host immunity and persistence. Edited by and published by Springer Science and Business Media.
Kuo, C. J., C. P. Ptak, C.L. Hsieh, B. L. Akey, and Y. F. Chang. 2013. Elastin, a Novel Extracellular Matrix Protein Adhering to Mycobacteria Antigen 85 Complex. J. Biol. Chem. 288:3886-3896.
Chen J.W., J. Scaria, C. Mao, B. Sobral, S. Zhang, T. Lawley, and Y. F. Chang. 2013. Proteomic comparison of historic and recently emerged hypervirulent Clostridium difficile strains. J Proteome Res. 12:1151-1161.
Faisal S.M., J. W. Chen1, F. Yan, T. T. Chen, N. M. Useh, W. Yan, S. Guo, S.J. Wang, A. L. Glaser, S. P. McDonough, B. Singh, W. C. Davis,  B. L. Akey, and Y. F. Chang. 2013. Evaluation of Mycobacterium avium subsp. paratuberculosis leuD mutant as vaccine candidate against challenge in a caprine model. Clin. Vaccine Immunol. 20:572-591.
Yan, W., M. H. Saleem, P. McDonough, S. P. McDonough,T. J.  Divers, Y. F. Chang. 2013. Development of an ELISA using recombinant LigACon4-7.5 as antigen for the diagnosis of equine leptospirosis. Clin Vaccine Immunol. 20:1143-1149.
Raman, R., C. P. Ptak, C. L. Hsieh, R. E. Oswald, Y. F. Chang and Y. Sharma.2013. The Perturbation of Tryptophan Fluorescence by Phenylalanine to Alanine Mutations Identifies the Hydrophobic Core in a Subset of Bacterial Ig-like Domains. Biochemistry. 52:4589-4591.
Faisal, S. M., Y. Falong, T.T. Chen, N. Useh, S. Guo, W,Yan, S. J. Wang, A. L. Glaser, S. P. McDonough, B.  Singh, and Y. F. Chang. 2013. Evaluation of a Salmonella vectored vaccine expressing Mycobacterium avium subsp. paratuberculosis antigens against challenge in a goat model. PLoS One. e70171.
Scaria, J., C. Mao, J. W. Chen, S, P. McDonough, B. Sobral, Y.F. Chang. 2013. Differential stress transcriptome landscape of historic and recently emerged hypervirulent strains of Clostridium difficile strains determined using RNA-seq. PLoS One. e78489.
Ye , C., W, Yan, P. L. McDonough, S. P. McDonough, H. Mohamed, T. J. Divers, Y. F. Chang, and Z. Yang. 2014. Serodiagnosis of equine leptospirosis by enzyme-linked immunosorbent assay using four recombinant protein markers. Clin Vaccine Immunol 21:478-83.
Scaria, J., J. W. Chen, N. Useh, H. He, S. P. McDonough, C. Mao, B. Sobral, and Y.F. Chang. 2014. Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays. Intl. J. Infect. Dis. 27:20-25.
Pereira, A.M., C. G. M. Pinheiro, N. C. Teixeira, Y. F. Chang, L. C. Pontes-de-Carvalho, and G. G. Oliveira. 2014. Requirement of dual stimulation by homologous recombinant IL-12 and recombinant L-12 for the in vitro production of interferon gamma by canine peripheral blood mononuclear cells. BMC Res. Notes. 7:460-469.
Bannantine, J. P.,  J. L. Everman, S. J. Rose, L.  Babrak, R. Katani, R. G. Barletta, A. M. Talaat, Y. T. Gröhn, Y. F. Chang, V. Kapur and L. E. Bermudez. 2014. Evaluation of eight live attenuated vaccine candidates for protection against challenge with virulent Mycobacterium avium subspecies paratuberculosis in mice. Frontiers in Cell. Infect. Microbiol. 4 (88):1-8.
Bannantine, J.P., M. E. Hines II, L. E. Bermudez, A. M. Talaat, S. Sreevatsan, J. R. Stabel1, Y.F. Chang, P. M. Coussens, R. G. Barletta, W. C. Davis, D. M. Collins, Y. T. Gröhn and V. Kapur. 2014. A Rationale Framework for Evaluating the Next Generation of Vaccines against Mycobacterium avium subspecies paratuberculosis. Frontiers in Cell. Infect. Microbiol. 4(88):1-11.
Kunjantarachot, A., W. Yan, S. P. McDonough, S. Prapong, G. Theeragool and Y. F. Chang. 2014. Immunogenicity of Leptospira interrogans Outer Membrane Vesicles in a Hamster Model. J vaccines Vaccination. 5:239 (1-9).
Silva, V., L. Soares, A. Junior, H. Mantovani, Y.F. Chang, and M. A. Moreira. 2014. Biofilm formation on biotic and abiotic surfaces in the presence of antimicrobials by Escherichia coli isolated from bovine mastitis. Applied Environ. Microbiol. 80:6136-6145.
Ptak, C.P., C. L. Hsieh, Y. P. Lin, A. S. Maltsev, R. Raman, Y. Sharma, R. E. Oswald, and Y. F. Chang. 2014. NMR solution structure of the terminal immunoglobulin-like domain from the Leptospira host-interacting outer membrane protein, LigB.  Biochemistry. 53:5249-5260.
Ye, C., Yan, W., Xiang, H., He, H., Yang, M., Ijaz, M., Useh, N., Hsieh, C. L., McDonough, P. L., McDonough, S. P., Mohamed, H., Yang, Z. & Chang, Y. F. 2014. Recombinant antigens rLipL21, rLoa22, rLipL32 and rLigACon4-8 for serological diagnosis of leptospirosis by enzyme-linked immunosorbent assays in dogs. PLoS ONE. 9(12):e111367.
Zeng, L.B., X.R. Zhuang, L.L. Huang, Y.Y. Zhang, C.Y. Chen, K. Dong, Y. Zhang, Z.L. Cui, X.L. Ding, Y.F. Chang, X.K. Guo, and Y.Z. Zhu. 2015. Comparative Subproteome Analysis of Three Representative Leptospira Interrogans Vaccine Strains Reveals Cross-reactive Antigens and Novel Virulence Determinants. J. Proteomics. 112:27-37.
Guo, S, Yan W, McDonough S.P, Lin N, Wu K.J, He H, Xiang H, Yang M, Moreira M.A.S, & Chang Y.F. 2015. The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model. Vaccine 33(13):1586-1595
Zhang, C, H. Yang, X. Li1, Z. Cao, H. Zhou, L. Zeng, J. Xu, Y. Xu, Y. F. Chang, X. Guo,Y. Zhu, X. Jiang. 2015. Molecular typing of pathogenic Leptospira serogroup Icterohaemorrhagiae strains circulating in China during the past 50 years. PLoS NTD, 9(5):e0003762
Scaria, J., H. Suzuki, C. P.  Ptak, J.W. Chen, Y. Zhu, X.K. Guo and Y.F. Chang (2015): Comparative genomic and phenomic analysis of Clostridium difficile and Clostridium sordellii, two related pathogens with differing host tissue preference.   BMC Genomics, 16:448 (1-16)
Zhang, Y., J. Sun, C. Mi, W. Li, S. Zhao, Q. Wang, D. Shi, L. Liu, B. Ding, H. Guo, Y. F.  Chang, X. Guo, Q. Li, & Y. Zhu. 2015. First Report of Two Rapid-Onset Fatal Infections Caused by a Newly Emerging Hypervirulent K. Pneumonia ST86 Strain of serotype K2 in China. Frontiers in Microbiol (Infect. Dis.). 6 (721):1-5.
Faisal, S.M., J. Scaria, and Y.F. Chang. 2015. Immunostimulatory- fusogenic and conventional liposome adjuvants Induce qualitatively and quantitatively distinct innate and adaptive immune responses. J. Immun. Res. 2:1020.
Su W, C, Wang , J, Luo ,Y, Zhao, Y, Wu, L. Chen, N, Zhao, M, Li, C, Xing, H, Liu, H, Zhang, Y. F. Chang, T, Li , H, Ding, X, Wan, & H, He. 2015. Testing the Effect of Internal Genes Derived from a Wild-Bird-Origin H9N2 Influenza A Virus on the Pathogenicity of an A/H7N9 Virus. Cell Rep. 12: 1831-1841.
Breda, L. C. D., Hsieh, C. L., Valencia, M. M. C., da Silva, L. B., Barbosa, A. S., Blom, A. M., Y. F. Chang, & Isaac, L. 2015. Fine mapping of the interaction between C4B-binding protein and outer membrane proteins LigA and LigB of pathogenic Leptopsira interrogans. PLoS Negl Trop Dis, 9, e0004192.
Kang, Y.X, Li, X.M., Piao,  D. R., Tian,  G.Z . , Jiang, H., Jia E.H., Lin,  L.,  Cui,  B.Y., Chang,  Y.F., Guo, X.K.,  and Zhu,  Y. Z. 2015. Typing discrepancy between phenotypic and molecular characterization revealing an emerging biovar 9 variant of smooth phage-resistant B. abortus strain 8416 isolated from a patient in China. Frontiers in Microbiol (Infect. Dis.). 6 (1375):1-8.
Xu, Y.,  Zhu^, Y., Wang, Y., Chang, Y.F., Zhang^, Y., Jiang, X.,  Zhuang, X.,  Zhu^, Y.,  Zhang J.,  Zeng, L., Yang, M., Li, S., Wang, S., Ye, Q., Xin, X.,  Zhao, G.,  Zheng, H.,  Guo, X., and Wang, J. 2016. Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira. Sci. Rep. 6:20020.
Fouts, D. E., Matthias, M. A., Adhikarla, H., Adler, B., Amorim-Santos, L., Berg, D. E., BUlach, D., Buschiazzo, A., Chang, Y. F., Galloway, R. L., Haake, D. A., Haaft, D. H., Hartskeerl, R., KO, A. I., Levett, P. N., Matsunaga, J., Mechalaay, A. E., Monk, J. M., Nascimento, A. L. T., Nelson, K. E., Palsson, B., Paecock, S. J., Picardeau, M., Ricaaldi, J. N., Thaipandungpanit, J., Wunder, E. A. J., Yang, X. F., Zhang, J. & Vinetz, J. M.  2016. What Makes a Bacterial Species Pathogenic?:  Comparative Genomic Analysis of the Genus Leptospira. PLoS Negl Trop Dis. 10(2):e0004403.
Chang YC, J. Scaria, M. Ibraham, S, Doiphode , Y. F. Chang, A. Sultan, H.O. Mohammed. 2016. Distribution and factors associated with Salmonella enterica genotypes in a diverse population of humans and animals in Qatar using multi-locus sequence typing (MLST). J Infect Public Health. 9:315-323.
Hsieh  CL, E. Chang, A. Tseng, C. Ptak, L. C. Wu, C.L. Su, S. P. McDonough, Y. P. Lin, and Y. F. Chang. 2016. Leptospira immunoglobulin-like protein B (LigB) binds to both the C-terminal 23 amino acids of fibrinogen aC domain and Factor XIII: Insight into the mechanism of LigB-mediated blockage of fibrinogen a chain cross-linking. PLoS Negl Trop Dis. 10(9):e0004974.
Zhang, F., S. Cao, Z. Zhu, Y. Yang, X. Wen, Y. F. Chang, X. Huang, R.Wu, Y.Wen , Q. Yan, Y. Huang, X. Ma and Q.  Zhao. 2016. Immunoprotective efficacy of six in vivo-induced antigens against Actinobacillus pleuropneumoniae as potential vaccine candidates in murine model.  Frontiers in Microbiol. 7:1623.
Faisal, S.M., V. P. Varma, M, Subathra, S, Azam, A. K. Sunkara, M. Akif, M. S. Baig, Y. F. Chang. 2016. Leptospira surface adhesin (Lsa21) induces Toll like receptor 2 and 4 mediated inflammatory responses in macrophages. Sci. Rep. 6:39530.
Ptak, C.P., C. J. Kuo, and Y. F. Chang. 2017. Chapter 20. Mycobacterium tuberculosis Antigen 85 Family Proteins: Mycolyl Transferases and Matrix‐Binding Adhesins. In Moonlight proteins: 9781118951118 Henderson (ed). Wiley-Blackwell.
Feng, H, S. P. McDonough, J. Fan, S. Yang , X. Zhao, Y.  Lu, Y. Gan, X. Yi, Y. F Chang. 2017. Phosphorylated Radix Cyathulae officinalis Polysaccharides Act as Adjuvant via Promoting Dendritic Cell Maturation. Molecules, 22, 106; 22010106.
Xu, Y., H. Zheng, Y. Zhang, Y. Wang, J. Zhang, Z. Li, S. Cui, X. Xin, Q. Ye, Y. F. Chang, and J. Wang. 2017. Genomic analysis of a new serovar of Leptospira weilii serogroup Manhao. Frontiers in Microbiol (Infect. Dis). 10:3389
Zeng, L., D. Wang, N. Hu, Q. Zhu, K. Chen, K.  Dong, Y. Zhang, Y. Yao, X.K. Guo, Y.F. Chang, Y. Zhu. 2017. A novel pan-genomic reverse vaccinology approach employing negative-selection strategy for screening surface-exposed antigens against leptospirosis. Frontiers in Microbiol (Infect. Dis). 8:149.
Hsieh C.L., A. Tseng, H. He, C. J. Kuo, X. Wang, Y.F. Chang. 2017. Leptospira Immunoglobulin-like Protein B Interacts with the 20th Exon of Human Tropoelastin Contributing to Leptospiral Adhesion to Human Lung Cells. Frontiers in Cell. Infect. Microbiol. 7:163.
Xia, B., L.Sun, X. Fan, H. Xiao, Y. Zhu, J. Qin, F. Wu, X. Ding, C. Cai, W. Zhao, K. Dong, Y.F. Chang, X. Guo, Y. Zhang, P. He^. 2017. A new model of self-resolving leptospirosis in mice infected with a strain of L. interrogans serovar Autumnalis harboring LPS signaling only through TLR4. Emerg. Microb. & Infect. 6:e36.
Hsieh C.L., C. P. Ptak, A. Tseng A, I.M.S. Suguiura,   S. P. McDonough, T, Li, Y. P. Lin, R. E. Gillilan, R. Oswald, Y.F. Chang. 2017. Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design. Elife. e30051
Ashraf A, Imran M, Yaqub T, Tayyab M, Shehzad W, Mingala CN, Chang YF. 2018. Development and validation of a loop-mediated isothermal amplification assay for the detection of Mycoplasma bovis in mastitic milk. Folia Microbiol (Praha). 263:373-380.
Dai, K., X. Wen, Y. F. Chang, S. Cao, Q. Zhao, X. Huang, R. Wu, Y. Huang, Q. Yan, X. Han, X. Ma, and Y. Wen. 2018. A streptomycin resistance marker in H. parasuis based on site-directed mutations in rpsL gene to perform unmarked in-frame mutations and to verify natural transformation. PeerJ 6:e4253.
Xu, K., Q. Zhao, X. Wen, R. Wu, Y. Wen, X. Huang, Y. Huang, Q. Yan, X. Han, X. Ma, Y. F. Chang, and S. Cao. 2018. A trivalent Apx-fusion protein delivered by E. coli outer membrane vesicles induce protection against Actinobacillus pleuropneumoniae of serotype 1 and 7 challenge in a murine model. PLoS One 13:e0191286.
Dai, K., L. He, Y. F.  Chang, S. Cao, Q. Zhao, X. Huang, R. Wu, Y. Huang, Q. Yan, X. Han, X. Ma, X. Wen Y. Wen^. 2018. Basic Characterization of natural transformation in a highly transformable Haemophilus parasuis strain SC1401. Frontiers in Cell. Infect. Microbiol. 8:32.
Zhou, Y., R. Wu, Q. Zhao, Y. F. Chang, X. Wen, Y. Feng, X. Huang, Y. Wen, Q. Yan, Y. Huang, X. Ma, X. Han, and S. Cao. 2018. Mutation of I176R in the E coding region weakens Japanese encephalitis virus neurovirulence, but not its growth rate in BHK-21 cells. Arch Virol. 163:1351-135.
Stevenson, T.C.,C. Cywes-Bentley, T.D. Moeller, K. B. Weyant, D. Putman, Y.F. Chang, B. D. Jones, G. B. Pier, and M. P. Delisa. 2018. Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly anti-microbial antibodies. PNAS. 115:E3106-E3115.
Ho PY, Chen YC, Maekawa S, Hu HH, Tsai AW, Chang YF, Wang PC, Chen SC.2018. Efficacy of recombinant protein vaccines for protection against Nocardia seriolae infection in the largemouth bass Micropterus salmoides. Fish Shellfish Immunol. 2018, 78:35-41.
Zhang F, Zhao Q, Tian J, Chang YF, Wen X, Huang X, Wu R, Wen Y, Yan Q, Huang Y, Ma X, Han X, Miao C, Cao S. 2018. Effective Pro-Inflammatory Induced Activity of GALT, a Conserved Antigen in A. pleuropneumoniae, Improves the Cytokines Secretion of Macrophage via p38, ERK1/2 and JNK MAPKs Signal Pathway. Front Cell Infect Microbiol. 2018, 25;8:33.
Zhang C, Li Z, Xu Y, Zhang Y, Li S, Zhang J, Cui S, Du Z, Xin X, Chang YF, Jiang X, Ye Q. 2018. Genetic diversity of Leptospira interrogans circulating isolates and vaccine strains in China from 1954-2014. Hum Vaccin Immunother. 2018, 27:1-7.
Ferreira JC, Penha Filho RAC, Kuaye APY, Andrade LN, Chang YF, Darini ALC. 2018. Virulence potential of commensal multidrug resistant Escherichia coli isolated from poultry in Brazil. Infect Genet Evol. 2018; 65:251-256.
Zhang F, Zhao Q, Quan K, Zhu Z, Yang Y, Wen X, Chang YF, Huang X, Wu R, Wen Y, Yan Q, Huang Y, Ma X, Han X, Cao S. 2018. Galactose-1-phosphate uridyltransferase (GalT), an in vivo-induced antigen of Actinobacillus pleuropneumoniae serovar 5b strain L20, provided immunoprotection against serovar 1 strain MS71. PLoS One. 13:e0198207.
Dos Santos LF, Costa Polveiro R, Scatamburlo Moreira T, Pereira Vidigal PM, Chang YF, Scatamburlo Moreira MA. 2018. Polymorphism analysis of the apxIA gene of Actinobacillus pleuropneumoniae serovar 5 isolated in swine herds from Brazil. PLoS One. 13:e0208789
Sasmal I, Gould NP, Schuler KL, Chang YF, Thachil A, Strules J, Olfenbuttel C, Datta S, DePerno CS. 2019. Leptospirosis in Urban and Suburban American Black Bears in Western North Carolina. J Wildl Dis. 55:74-83.
Ptak CP, Akif M, Hsieh CL, Devarajan A, He P, Xu Y, Oswald RE, Chang YF. 2019. Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design. Biotechnol. Bioeng. 116:260-271.
Hou C, Yi B, Jiang J, Chang YF, Yao X. 2019. Up-to-date vaccine delivery systems: robust immunity elicited by multifarious nanomaterials upon administration through diverse routes. Biomater Sci. 7(3): 822-835.
Liu J, Hsieh CL, Gelincik O, Devolder B, Sei S, Zhang S, Lipkin SM, Chang YF. 2019. Proteomic characterization of outer membrane vesicles from gut mucosa-derived Fusobacterium nucleatum. J Proteomics. 195:125-137.
Li XM, Lin  L, Jia EH, Piao, D, Jiang, H, Zhang, CC, He J, Chang YF, Guo XK, Zhu YZ, Kang YX. 2019. Genomic Characterization provides new insights for detailed phage-resistant mechanism for Brucella abortus. Frontier Microbiol. 10:917.
Zhang C, Xu J, Zhang T, Qiu H, Li Z, Zhang E, Li S, Chang YF, Guo X, Jiang X, Zhu Y.2019. Genetic characteristics of pathogenic Leptospira in wild small animals and livestock in Jiangxi Province, China, 2002-2015. PLoS Negl Trop Dis. 13:e0007513.
Yuan Y, Li Y, Wang G, Li C, Chang YF, Chen W, Nian S, Mao Y, Zhang J, Zhong F, Zhang L. 2019. bla _NDM-5 carried by a hypervirulent Klebsiella pneumoniae with sequence type 29. Antimicrob Resist Infect Control. 8:140.
Dai K, Yang Z,  Chang YF,  He L,  Cao S,  zhao Q,  Huang X,  Wu R, Huang Y, Yan Q,  Han X,  Ma X, Wen X, Wen Y. 2019. Construction of targeted and integrative promoter-reporter plasmids pDK-K and pDK-G to measure gene expression activity in Haemophilus parasuis. Microbial Pathog. 134:103565.
Zhao Q, Yang ZS, Cao SJ, Chang YF, Cao YQ, Li JB, Yao ZX, Wen YP, Huang XB, Wu R, Yan QG, Huang Y, Ma XP, Han XF, Wu Y. 2019. Acute oral toxicity test and assessment of combined toxicity of cadmium and aflatoxin B₁ in kunming mice. Food Chem Toxicol. 131:110577.
Lee JJ, Hsieh CL, Widman J, Mingala C, Ardeza Villanueva M, Feng H, Divers T, Chang YF. 2019.  A luminescence-based assay for evaluating bactericidal antibody to Borrelia burgdorferi in vaccinated horses’ serum. Equine Vet J. 2019 Sep;51(5):669-673. doi: 10.1111/evj.13074.
Divers TJ, Chang YF, Irby NL, Smith JL, Carter CN. 2019. Leptospirosis: An important infectious disease in North American horses. Equine Vet J. 2019 May;51(3):287-292. doi: 10.1111/evj.13069.
Chang YF, Hou JN, Lin HH, Wu CP, Chu C.2019. Differences in immune responses of pigs vaccinated with Salmonella Typhimurium and S. Choleraesuis strains and challenged with S. Choleraesuis. Comp Immunol Microbiol Infect Dis. 65:41-47.
Kuo CJ, Gao J, Huang JW, Ko TP, Zhai C, Ma L, Liu W, Dai L, Chang YF, Chen TH, Hu Y, Yu X, Guo RT, Chen CC. 2019. Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis. Biochim Biophys Acta Gen Subj. 1863:1351-1359.
Lin W, Chen T, Liao L, Wang Z, Xiao J, Lu J, Song C, Qin J, Chen F,  Chang YF, Xie Q. 2019. A parrot-type Chlamydia psittaci strain is in association with egg production drop in laying ducks. Transbound Emerg Dis. Transbound Emerg Dis. 66:2002-2010.
Cao YQ, Yuan L, Zhao Q, Yuan JL, Miao C, Chang YF, Wen XT, Wu R, Huang XB, Wen YP, Yan QG, Huang Y, Han XF, Ma XP, Cao SJ. 2019. Hsp40 Protein DNAJB6 Interacts with Viral NS3 and Inhibits the Replication of the Japanese Encephalitis Virus. Int J Mol Sci. 2019 Nov 14;20(22).
Assao VS, Scatamburlo TM, Araujo EN, Santos MR, Pereira CER, Guedes RMC, Bressan GC, Fietto JLR, Chang YF, Moreira MAS, Silva-Júnior A. 2019. Genetic variation of Mycoplasma hyopneumoniae from Brazilian field samples. BMC Microbiol. 2019 Oct 28;19(1):234.
Dai K, Ma X, Yang Z, Chang YF, Cao S, Zhao Q, Huang X, Wu R, Huang Y, Yan Q, Han X, Ma X, Wen X, Wen Y. 2019. Polyamine Transport Protein PotD Protects Mice against Haemophilus parasuis and Elevates the Secretion of Pro-Inflammatory Cytokines of Macrophage via JNK-MAPK and NF-κB Signal Pathways through TLR4. Vaccines (Basel), 7 (4): 7040216
Zhang H, Zhang C, Zhu Y, Khalid M, Liu J, McDonough SP, Tang Z, Chang YF.2020. Leptospirosis Trends in China, 2007-2018: a retrospective observational study. Transbound Emerg Dis. 67(3):1119-1128.
Reingewertz TH, Meyer T, McIntosh F, Sullivan J, Meir M, Chang YF, Behr MA, Barkan D. 2020. Differential sensitivity of mycobacteria to isoniazid is related to differences in KatG-mediated enzymatic activation of the drug. Antimicrob Agents Chemother. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01899-19. doi: 10.1128/AAC.01899-19. Print 2020 Jan 27.
Guo R, Tian Y, Zhang H, Guo D, Pei X, Wen H, Li P, Mehmood K, Yang K, Chang YF, Liu Z, Duan Z, Yuan F, Liu W, Fazlani SA.2020. Biological Characteristics and Genetic Evolutionary Analysis of Emerging Pathogenic Bacillus Cereus Isolated From Père David’s Deer (Elaphurus Davidianus). Microb Pathog, 2020 Mar 10;143:104133. doi: 10.1016/j.micpath.2020.104133..
Li, T, Zhang Y, Dong K, Kuo C-J, Li C, Zhu Y, Qin J, Li Q, Chang Y.F, Guo X, and Zhu Y. 2020. Isolation and characterization of the novel phage JD032 and global transcriptomic response during JD032 infection of RT078 C. difficile. mSystem. 5(3):e00017-20. v Wang Y, Liao J, Mehmood K, Chang YF, Tang Z, Zhang H.2020. Escherichia coli Isolated in Pigs, Guangdong, China: Emergence of Extreme Drug Resistance (XDR) Bacteria. J. Infect. 81(2):318-356.
Zhang H, Mehmood K, Chang YF, Zhao Y, Lin W, Chang Z. 2020. Increase in cases of dengue in China, 2004-2016: A retrospective observational study. Travel Med Infect Dis. 20:101674.
Yang X, Xia YH, Wang JY, Li YT, Chang YF, Chang HT, Liu HY, Chen L, Wang CQ. 2020. The role of GtxA during Gallibacterium anatis infection of primary chicken oviduct epithelial cells. Mol Cell Probes. 53:101641.
Lin W, Zhou L, Liu M, Zhang D, Yan Y, Chang YF, Zhang X,XIE Q, Luo Q. 2020. miR-200b-3p promotes macrophage activation and differentiation via targeting monocyte to macrophage differentiation-associated in HD11 cells. Frontiers Immunol. 11:563143.
Zilch TJ, Lee JJ, Bressan GC, McDonough SP, Mohammed HO, Divers TJ, Chang YF.  2021. Evaluation of new leptospiral antigens for the diagnosis of equine leptospirosis: An approach using pan-genomic analysis, reverse vaccinology, and antigenic selection. Equine Vet J. evj.13380.
Caldeira JLA, Faria ACS, Diaz-Miranda EA, Zilch TJ, da Costa Caliman SL, Okano DS, Guimarães JD, Pena JL, Barbosa WF, Junior AS, Chang YF, Moreira MAS. 2021. Interaction of Mycobacterium avium subsp. paratuberculosis with bovine sperm. Theriogenology. 161:228-236.
Pang, Y, Cong F, Zhang X, Li H, Chang YF, Xie Q, Lin W. 2021. A recombinase polymerase amplification–based assay for rapid detection of Chlamydia psittaci. Poultry Sci. 100:585-591.
Dai K, Yang Z, Ma X, Chang YF, Cao S, Zhao Q, Huang X, Wu R, Huang Y, Xia J, Yan Q, Han X, Ma X, Wen X, Wen Y.2021. Deletion of Polyamine Transport Protein PotD Exacerbates Virulence in Glaesserella (Haemophilus) parasuis in the Form of Non-biofilm-generated Bacteria in a Murine Acute Infection Model. Virulence. 12:520-546.
Zhang, H, Dong H, Liu B, Li A, Mehmood K, Jamail T, Chang YF, Wu Q. 2021. Microbiome analysis reveals the attenuation effect of Lactobacillus from yaks on diarrhea via modulation of gut microbiota Front Cell Infect Microbiol, 10:61078.
Zilch TJ, Lee JJ, Saleem, MZ, Zhang, H, Cortese, V, Voris, N, McDonough SP, Divers TJ, Chang YF.  2021. Equine leptospirosis: Experimental challenge of Leptospira interrogans serovar Bratislava fails to establish infection in naïve horses. Equine Vet J. evj.13442.
Assao VS, Santos MR, Rosado NCL, Bressan GC, Fietto JLR, Chang YF, Vidigal PMP, Silva-Júnior A. 2021. Genetic diversity of porcine circovirus 3 strains and the first detection of two different PCV3 strains coinfecting the same host in Minas Gerais, Brazil. Arch Virol. 2021 Mar 15. doi: 10.1007/s00705-021-05032-y. Online ahead of print.
Li A, Wang Y, He Y, Liu B, Iqbal M, Mehmood K, Jamil T, Chang YF, Hu L, Li Y, Guo J, Pan J, Tang Z, Zhang H. 2021. Environmental fluoride exposure disrupts the intestinal structure and gut microbiota a alteration in duck. Chemosphere. 277:130222.
Dong H, Liu B, Li A, Iqbal M, Mehmood K, Jamil T, Chang YF, Zhang H, Wu Q.2021. Microbiome Analysis Reveals the Attenuation Effect of Lactobacillus From Yaks on Diarrhea via Modulation of Gut Microbiota. Front Cell Infect Microbiol. 2021 Feb 16;10:610781.
Liu B, Mehmood K, Nabi F, Chang YF, Tang Z, Li Y, Zhang H. 2021. Mosquito-Borne Infectious Diseases in China, 2019. Travel Med Infect Dis. 2021 Apr 1:102050.
Wang Y, Fan X, Du L, Liu B, Xiao H, Zhang Y, Wu Y, Liu F, Chang YF, Guo X, He P. 2021. Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages. Emerg Microbes Infect 10:939-953.
Xu K, Zhao Q, Jiang HZ, Mou XR, Chang YF, Cao YQ, Miao C, Wu R, Wen YP, Huang XB, Yan QG, Du SY, Cao SJ. 2021. Molecular and functional characterization of HtrA protein in Actinobacillus pleuropneumoniae. Vet Microbiol 257:109058.
Xi L, Song Y, Qin X, Han J, Chang YF. 2021. Microbiome Analysis Reveals the  Dynamic Alternations in Gut Microbiota of Diarrheal Giraffa Camelopardalis.Front Vet Sci. 8:649372.
Xiao J, Li Y, Hu Z, Zhang Y, Chang YF, Zhou Q, Yan Z, Zhang X, Chen L, Li W, Xie Z, Xie Q.2021. Characterization of Pasteurella multocida isolated from ducks in China from 2017 to 2019. Microb Pathog.  15;160:105196.
Zhu S, Liu Y, Li Y, Yi J, Yang B, Li Y, Ouyang Z, Liu B, Shang P, Mehmood K, Abbas RZ, Ahmed S, Chang YF, Guo J, Pan J, Hu L, Tang Z, Li Y, Zhang H. 2021.The potential risks of herbicide butachlor to immunotoxicity via induction of autophagy and apoptosis in the spleen. Chemosphere, 26;286:131683.
Chou S, Li Q, Wu H, Li J, Chang YF, Shang L, Li J, Wang Z, Shan A.2021. Selective Antifungal Activity and Fungal Biofilm Inhibition of Tryptophan Center Symmetrical Short Peptide. Int J Mol Sci. 30;22(15):8231.
Li Y, Liu Y, Yi J, Li Y, Yang B, Shang P, Mehmood K, Bilal RM, Zhang H, Chang YF, Tang Z, Wang Y, Li Y. 2021. The potential risks of chronic fluoride exposure on nephrotoxic via altering glucolipid metabolism and activating autophagy and apoptosis in ducks.Toxicology, 461:152906. doi: 10.1016/j.tox.2021
Kumar A, Varma VP, Sridhar K, Abdullah M, Vyas P, Ashiq Thalappil M, Chang YF, Faisal SM. 2021. Deciphering the Role of Leptospira Surface Protein LigA in Modulating the Host Innate Immune Response.Front Immunol. 12:807775.
Li Y, Mehmood K, Chang YF, Guo R, Shang P, Zhang H. 2021.  Antibiotic resistance genes in Bacillus cereus isolated from wild Père David’s deer (Elaphurus davidianus). J Infect. 83:709-737.
Liao J, Liu Y, Yi J, Li Y, Li Q, Li Y, Shang P, Guo J, Hu L, Pan J, Li Y, Chang YF, Tang Z, Zhang H. 2022 Gut microbiota disturbance exaggerates battery wastewater-induced hepatotoxicity through a gut-liver axis. Sci Total Environ. 809:152188.
Chou S, Zhang S, Guo H, Chang YF, Zhao W, Mou X. 2022. Targeted Antimicrobial Agents as Potential Tools for Modulating the Gut Microbiome. Front Microbiol 13:879207.
Hou C, Chang YF, Yao X. 2022. Supramolecular Adhesive Materials with Antimicrobial Activity for Emerging Biomedical Applications. Pharmaceutics 14:1616.
Kumar P, Chang YF, Akif M. 2022. Characterization of novel nuclease and protease activities among Leptospiral immunoglobulin-like proteins. Arch Biochem Biophys 727:109349.
Li Y, Xu W, Ren Y, Cheung HC, Huang P, Kaur G, Kuo CJ, McDonough SP, Fubini SL, Lipkin SM, Deng X, Chang YF, Huang L. 2022. Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB. mBio doi:10.1128/mbio.01849-22:e0184922.
Liao J, Liu Y, Yi J, Li Y, Li Q, Li Y, Shang P, Guo J, Hu L, Pan J, Li Y, Chang YF, Tang Z, Zhang H. 2022. Gut microbiota disturbance exaggerates battery wastewater-induced hepatotoxicity through a gut-liver axis. Sci Total Environ 809:152188.
Tang S, Li J, Chang YF, Lin W. 2022. Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication. Front Immunol 13:907287.
Tang X, Yang Z, Dai K, Liu G, Chang YF, Tang X, Wang K, Zhang Y, Hu B, Cao S, Huang X, Yan Q, Wu R, Zhao Q, Du S, Lang Y, Han X, Huang Y, Wen X, Wen Y. 2022. The molecular diversity of transcriptional factor TfoX is a determinant in natural transformation in Glaesserella parasuis. Front Microbiol 13:948633.
Wu Z, Liu J, Chen S, Zhang H, Chang YF, Zhang X, Xie Q. 2022. The emergence of the novel avian influenza virus (H10N3) in China, 2020-a cause for concern? J Infect 84:e16-e18.
Xu G, Qiu H, Liu W, Jiang X, Chang YF, Wang J, Li Z, Zhu Y, Zhang C, Xiao F. 2022. Serological and molecular characteristics of pathogenic Leptospira in rodent populations in Fujian Province, China, 2018-2020. BMC Microbiol 22:151.
Yang Z, Tang X, Wang K, Dai K, Chang YF, Du S, Zhao Q, Huang X, Wu R, Yan Q, Cao S, Wen Y. 2022. Metal Ion Periplasmic-Binding Protein YfeA of Glaesserella parasuis Induces the Secretion of Pro-Inflammatory Cytokines of Macrophages via MAPK and NF-kappaB Signaling through TLR2 and TLR4. Int J Mol Sci 23:9627.
de Souza LFL, Campbell G, Arthuso GGS, Gonzaga NF, Alexandrino CR, Assao VS, Moreira MAS, Da Cunha M, Chang YF, Silva-Júnior A. 2022. Identification of extracellular vesicles from J strain and wild isolate of Mycoplasma hyopneumoniae. Braz J Microbiol.53:1081-1084
Yi J, Li Y, Mai Q, Li Y, Lin Y, Weng X, Ai Z, Li M, Shang P, Iqbal M, Mehmood K, Chang YF, Tang Z, Zhang H, Li Y. 2022. Hepatotoxicity and the role of the gut-liver axis in dogs after oral administration of zinc oxide nanoparticles. Metallomics doi:10.1093/mtomcs/mfac066.
Zhang H, Chang YF, Liu J. 2022. Editorial: Regulation of Mitochondrial Function on Animal Diseases. Front Vet Sci 9:943860.
Zhou N, Cheng Z, Zhang X, Lv C, Guo C, Liu H, Dong K, Zhang Y, Liu C, Chang YF, Chen S, Guo X, Zhou XN, Li M, Zhu Y. 2022. Global antimicrobial resistance: a system-wide comprehensive investigation using the Global One Health Index. Infect Dis Poverty 11:92.
Zhu S, Liu Y, Li Y, Yi J, Yang B, Li Y, Ouyang Z, Liu B, Shang P, Mehmood K, Abbas RZ, Ahmed S, Chang YF, Guo J, Pan J, Hu L, Tang Z, Li Y, Zhang H. 2022. The potential risks of herbicide butachlor to immunotoxicity via induction of autophagy and apoptosis in the spleen. Chemosphere 286:131683.
Li Y, Xiao J,  Chang YF, Zhang H, Teng Y, Lin W, Li H, Chen W, Xinheng Zhang X,  Xie Q. 2022. Immunogenicity and protective efficacyof the recombinant Pasteurella multocida lipoprotein J, E, and outer membrane protein H from P. multocidaA:1 in ducks. Frontiers Immunol. 13:985993.
Prapong S, Tansiri Y, Sritrakul T, Sripattanakul S,Sopitthummakhun A, Katzenmeier G, Hsieh CL, Sean P. McDonough SP,Prapong T and Chang YF. 2022. Leptospira borgpetersenii Leucine-Rich Repeat Proteins Provide Strong Protective Efficacy as Novel Leptospiral Vaccine Candidates. Trop. Med. Infect. Dis, 8: 6.
2023
Warfel KF, Williams A, Wong DA, Sobol SE, Desai P, Li J, Chang YF, Delisa MP, Karim AS, Jewett MC. 2023. Low-Cost, thermostable, cell-Free Protein synthesis platform for on-demand production of conjugate vaccines. ACS Synth Biol. 12:95-107.
Asher JW, Warfel KF, Desai P,  Li J,  Lee JJ, Wong DA, Sobol SE, Jewett MC, Chang YF, DeLisa MP. 2023 A low-cost recombinant glycoconjugate vaccine confers immunogenicity and protection against enterotoxigenic Escherichia coli infections in mice. Front. Mol. Biosci. 10:1085887.
Li Y, Xiao J, Cai Q, Chang YF, Li R, He X, Teng Y, Zhang H, Zhang X, Xie Q. 2023. Whole genome characterization of a multidrug-resistant hypervirulent Pasteurella multocida with a new drug-resistant plasmid. Poultry Sci. 102:102583.
Liang W, Xiao H, Chen JY, Chang YF, Cao SJ, Wen YP, Wu R, Du SY, Yan QG, Huang XB, Zhao Q. 2023. Immunogenicity and protective efficacy of a multi-epitope recombinant toxin antigen of Pasteurella multocida against virulent challenge in mice. Vaccine 41:2387-2396.
Zhang H, Rehman MU, Chang YF, Zhaoxin T. 2023. Editorial: The potential role of gut microbiome in animal gut-linked diseases. Front Microbiol.14:1179481.
Liu G, Wang K, Yang Z, Tang X, Chang YF, Dai K, Tang X, Hu B, Zhang Y, Cao S, Huang X, Yan Q, Wu R, Zhao Q, Du S, Wen X, Wen Y. 2023. Identification of a Novel Linear B-Cell Epitope of HbpA Protein from Glaesserella parasuis Using Monoclonal Antibody. Int J Mol Sci. 24:8638.
Kumar P, Vyas P, Faisal SM, Chang YF, Akif M. 2023. Crystal structure of a variable region segment of Leptospira host-interacting outer surface protein, LigA, reveals the orientation of Ig-like domains. Intl J Biol Macromol. Int J Biol Macromol. 244:125445.
Tang S, Leng M, Tan C, Zhu L, Pang Y, Zhang X, Chang YF, Lin W. Critical role for ribonucleoside-diphosphate reductase subunit M2 in ALV-J-induced activation of Wnt/β-catenin signaling via interaction with P27. J Virol. 2023 Aug 31;97(8):e0026723.
Cai Q, Li Y, Chang YF, Tang Z, Zhang H, Xie Q.  Pasteurella multocida causes liver injury in ducks by mediating inflammatory, apoptotic and autophagic pathways. Microb Pathog. 2023 Sep 6:106336.
Yang Z, Zhang Y, Du S, Zhao Q, Huang X, Wu R, Yan Q, Han X, Cao S, Chang YF, Wen Y. Upregulation of occludin by cytolethal distending toxin facilitates Glaesserella parasuis adhesion to respiratory tract cells. Infect. Immun. 2023. 91(12):e0035123.
Chen Y, Mehmood K, Chang YF, Tang Z, Li Y, Zhang H. The molecular mechanisms of glycosaminoglycan biosynthesis regulating chondrogenesis and endochondral ossification. Life Sci. 2023. 335:122243.
Huang J, Lv C, Li M, Rahman T, Chang YF, Guo X, Song Z, Zhao Y, Li Q, Ni P, Zhu Y. Carbapenem-resistant Escherichia coli exhibit diverse spatiotemporal epidemiological characteristics across the globe. Commun Biol. 2024 Jan 6;7(1):51.
Santos MR, Toledo LT, Bassi ÊJ, Porto WJN, Bressan GC, Moreira MAS, Chang YF, Silva-Júnior A.  Chimeric proteins of Mycoplasma hyopneumoniae as vaccine and preclinical model for immunological evaluation. Braz J Microbiol. 2024 Jan 13. doi: 10.1007/s42770-023-01240-7.
Lee JJ, Abdullah M, Liu J, Carvalho IA, Junior AS, Moreira MAS, Mohammed H, DeLisa MP, McDonough SP, Chang YF.  Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins. J Proteomics. 2024 Feb 10;292:105058.
Zhang C, Fu L, Zhu Y, Chen Q, Chen Z, Chang Y-F, Li Y, Yao M, Huang X, Jin L, Gao X, Zhang Y, Jin B, Chou S, Luo L.  Antimicrobial activity of novel symmetrical antimicrobial peptides centered on a hydrophilic motif against resistant clinical isolates: in vitro and in vivo analyses. Microbiol Spectr. 2024 Nov 5;12(11):e0026524.
Lv C, Abdullah M, Chen W, Zhou N, Cheng Z, Chen Y, Li M, Simpson KW, Elsaadi A, Zhu Y, Lipkin SM, Chang YF. Genomic characterization of Escherichia coli harbor a polyketide synthase ( pks ) island associated with colorectal cancer (CRC) development. bioRxiv [Preprint]. 2024 Jun 17:2024.06.16.599199.
Li Y, Chen L, Xiao J, Feng K, Zhang X, Chang YF, Xie Q. Immunoprotective efficacy of Escherichia coli-derived outer membrane vesicles displaying PlpE protein of Pasteurella multocida. Vaccine (2025) 44: 126532,